Derivatization of pillared silicon substrates using poly(ethylene glycol) and 1-dodecanethiol
نویسندگان
چکیده
Surfaces that exhibit hydrophobic and hydrophilic characteristics are essential when developing Lab-onChip technologies. The availability of a droplet to be maneuvered on a surface develops from hydrophobic surface characteristics, while non-protein fouling characteristics are found in hydrophilic surfaces. By combining these traits, an ideal surface can be produced for biomedical applications. To satisfy these surface requirements, we have attached 8-arm hydroxyl-terminated poly(ethylene glycol) to silicon oxide and methyl-terminated 1-dodecanethiol to gold. By applying these techniques to a pillared substrate the result is hydrophilic poly(ethylene glycol) covalently bonded to pillar tops and hydrophobic 1-dodecanethiol bound to pillar sides and troughs. This creates a surface where the hydrophobic pillar sides and troughs suspend a droplet for movement while the hydrophilic pillar tops prevent loss of essential proteins.
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